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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $128 | In Stock | |
5 mg | $302 | In Stock | |
10 mg | $453 | In Stock | |
25 mg | $761 | In Stock | |
50 mg | $997 | In Stock |
Description | Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2. |
In vitro | Pretreatment with high doses of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (>25 μg/ml) improves the antimicrobial activity of neutrophils generated directly from mouse bone marrow. [3] |
In vivo | METHODS: Mice were intraperitoneally (ip) injected with Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (5 mg/kg) from postnatal day (PND) 3 to 11. Pups were killed at PND12 or PND53, and brains, spleens, and livers were collected and weighed. Brain sections were stained for markers of brain injury. RESULTS Nine days after administration of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA), mice showed a decrease in gray matter volume, white matter volume in the molecular layer of the forebrain and cerebellum, and an increase in spleen and liver weight at PND12. [1] |
Alias | Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA |
Molecular Weight | 1852.33 |
Formula | C87H159F9N10O19S |
Cas No. | 112208-01-2 |
Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O: Soluble |
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