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Pam3CSK4 TFA (112208-00-1 free base)
Catalog No. TP1067Cas No. 112208-01-2
Alias Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.
Pam3CSK4 TFA (112208-00-1 free base)
Catalog No. TP1067Alias Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFACas No. 112208-01-2
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $128 | In Stock | |
| 5 mg | $302 | In Stock | |
| 10 mg | $453 | In Stock | |
| 25 mg | $761 | In Stock | |
| 50 mg | $997 | In Stock |
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Purity:99.01%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2. |
| In vitro | Pretreatment with high doses of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (>25 μg/ml) improves the antimicrobial activity of neutrophils generated directly from mouse bone marrow. [3] |
| In vivo | METHODS: Mice were intraperitoneally (ip) injected with Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) (5 mg/kg) from postnatal day (PND) 3 to 11. Pups were killed at PND12 or PND53, and brains, spleens, and livers were collected and weighed. Brain sections were stained for markers of brain injury. RESULTS Nine days after administration of Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA), mice showed a decrease in gray matter volume, white matter volume in the molecular layer of the forebrain and cerebellum, and an increase in spleen and liver weight at PND12. [1] |
| Alias | Pam3Cys-Ser-(Lys)4 TFA, Pam3CSK4 TFA |
| Molecular Weight | 1852.33 |
| Formula | C87H159F9N10O19S |
| Cas No. | 112208-01-2 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | H2O: 16.67 mg/mL (9 mM), Sonication and heating are recommended.  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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